Life Extension has changed to new product packaging and all products are transitioning to this new packaging in the coming weeks. The product is the same excellent product you have always expected from Life Extension, only the packaging has changed.
Restore circadian rhythms for better sleep & overall health
Our NEW Circadian Sleep formula combines melatonin with a unique citrus-peel extract to encourage healthy function of both central and peripheral circadian clocks, respectively. MicroActive® Melatonin promotes optimal sleep-wake cycles, and nobiletin from young citrus peel supports healthy expression of genes that govern your peripheral circadian rhythms.
Benefits at a Glance:
- Promotes healthy whole-body circadian rhythms1-3
- Supports healthy sleep-wake cycles1
- Helps maintain whole-body health
- Contains both melatonin and nobiletin citrus extract
More facts about Circadian Sleep
You’ve probably heard of circadian rhythms — they’re best-known for regulating your sleep-wake cycles. In addition to the central circadian “clock” in your brain, the internal-time keeper that regulates sleep, you also have peripheral circadian clocks in various organs that govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function, and more.4-6
But aging, hectic modern lifestyles, and other factors can disrupt all of your circadian clocks — which can affect your health.7-9 So we developed our Circadian Sleep formula to restore these natural rhythms: MicroActive® Melatonin targets the central clock in your brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of your body.
Melatonin for healthy sleep-wake cycling
Peripheral circadian clocks exist in virtually every cell of your body and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.1 Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland.10 Melatonin ensures that the central clock is properly regulating sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.
So the first step to healthy, whole-body circadian rhythms is to restore that central clock with Melatonin.
Nobiletin for healthy peripheral circadian rhythms
Nobiletin is a polymethoxylated flavone isolated from young citrus peel. It has been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.11
Results from a recent pre-clinical study suggest that nobiletin may also help positively regulate peripheral circadian rhythms.2 It does so by directly activating a unique set of receptors widely expressed throughout the body,12 and known to play a key role in regulating circadian rhythms.13-16
Nobiletin promotes whole-body health
In another pre-clinical study, nobiletin regulates the expression of circadian genes which themselves control the expression of other genes with specific circadian functions in every cell.3 Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver, and kidney health and also helps maintain healthy blood pressure, cholesterol, and triglyceride levels already within the normal range.17-20
Unique circadian health formula
By targeting both “central” and “peripheral” circadian clocks, our Circadian Sleep represents a novel, restorative approach to whole-body health. Try Circadian Sleep today!
Serving Size 1 liquid vegetarian capsule
|Amount Per Serving
|Nobiletin [from young citrus fruit (peel)]
Melatonin (as MicroActive®)
Other ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnauba wax, silica.
|MicroActive® Melatonin is a registered trademark of Bioactives LLC.
|Dosage and Use
- Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
- Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.
Do not consume alcohol, drive or operate machinery after taking this product.
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.